Journal: PLoS ONE

Article Title: Regulation of T Cell Differentiation and Alloimmunity by the Cyclin-Dependent Kinase Inhibitor p18ink4c

doi: 10.1371/journal.pone.0091587

Figure Lengend Snippet: Kaplan-Meier survival curves for B6 (red lines), p27 kip1 −/− (blue lines) and p18 ink4c −/− (green lines) B6 recipients of BALB/c heterotopic cardiac allograft treated with control Ig ( A , 200 µg i.p. on days 0, 2, and 4), CTLA-4Ig ( B , 200 µg i.p. on days 0, 2, and 4) or anti-CD154 mAb ( C , MR1, 200 µg i.v. on day 0). Mean survival times (MST) for the control Ig groups are: B6 MST = 7, n = 3; p27 kip1 −/− MST = 7, n = 3, p18 ink4c −/− MST = 7, n = 3. MST for the CTLA-4Ig groups are: B6 MST = 18 days, n = 9; p27 kip1 −/− MST = 17 days, n = 5; p18 ink4c −/− MST = 60 days, n = 4, p<0.05. MST for the anti-CD154 groups are: B6 MST = 55 days, n = 5, p27 kip1 −/− MST = 57 days, n = 5, p18 ink4c −/− MST>135 days, n = 5, p<0.05.

Article Snippet: Transplant recipients received combined costimulatory blockade as indicated, consisting of anti-CD154 mAb (MR1, BioExpress, 200 μg/mouse, i.v.) administered on the day of transplant, and CTLA4-Ig (BioExpress, 200 μg i.p.) administered intraperitoneally on days 0, 2, and 4 post-transplant.

Techniques: Control

Journal: Xenotransplantation

Article Title: SAFE USE OF ANTI-CD154 MONOCLONAL ANTIBODY IN PIG ISLET XENOTRANSPLANTATION IN MONKEYS

doi: 10.1111/xen.12283

Figure Lengend Snippet: Post-transplant follow-up of recipient monkeys

Article Snippet: ABI793 monoclonal antibody was a gift from Novartis.

Techniques:

Journal: Xenotransplantation

Article Title: SAFE USE OF ANTI-CD154 MONOCLONAL ANTIBODY IN PIG ISLET XENOTRANSPLANTATION IN MONKEYS

doi: 10.1111/xen.12283

Figure Lengend Snippet: immunosuppressive and supportive therapy

Article Snippet: ABI793 monoclonal antibody was a gift from Novartis.

Techniques: Cell Counting, Transplantation Assay